导师风采

姜宏

  • 学院:生命科学与健康学院

  • 职称:教育部新世纪优秀人才

  • 学科名称:神经生物学、生理学

  • 专业领域:神经退行性疾病的病因及其防治对策

  • jianghong@uhrs.edu.cn

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  • 个人简介

  • 科研项目

  • 代表性成果

(一)学习与工作经历:

【学习经历】

1992/09-1997/07,青岛大学,临床医学,学士

1997/09-2000/07,青岛大学,生理学,硕士

2001/09-2004/07,青岛大学,生理学,博士

【工作经历】

2000/07-2022/09,青岛大学医学院,讲师、副教授、教授

2002/03-2002/09,香港理工大学,助理研究员

2007/01-2008/01,美国Sun Health Research Institute,博士后

2021/09-2022/09,青岛大学,副校长

2022/09-至今,康复大学,副校长、教授


(二)研究方向:

主要从事蛋白质稳态调控在神经退行性疾病中的作用及神经康复相关研究。先后主持国家自然科学基金面上项目、山东省重大科技创新工程项目及山东省自然科学基金重大基础研究项目等。以通讯作者在Cell Research、Nature Communications、Advanced Science等国际专业期刊发表系列论文80余篇。获省级教学成果一等奖、教育部自然科学二等奖、省科技进步二等奖等奖励。


(三)学术/社会兼职:

中国生理学会常务理事,中国神经科学学会常务理事,中华医学会医学教育分会委员,山东生理学会副理事长


1.国家自然科学基金面上项目,32371013,AGTR1对黑质铁代谢调控的新机制及在帕金森病中的作用,2024.01-2027.12,50万,在研。

2.国家自然科学基金面上项目,32171131,α-突触核蛋白经延髓-脑桥-黑质通路传播在帕金森病病程进展中的作用机制研究,2022.01-2025.12,58万,在研。

3.国家自然科学基金面上项目,31771110,铁调节蛋白IRP2的去泛素化酶鉴定及其在帕金森病黑质铁聚集中的作用研究,2018.01-2021.12,63万,结题。

4.山东省重点研发计划(重大科技创新工程),2021ZDSYS11,基于帕金森病铁沉积和蛋白质聚集的靶标研究与海洋药物研发,2021.12-2024.12,200万,结题。

5.山东省自然科学基金重大基础研究项目,ZR2019ZD31,去泛素化酶OTUD3参与帕金森病黑质多巴胺能神经元死亡的分子机制研究,2019.12-2024.12,177万,结题。


1. Han F, Liu M, Jiao Q, Du X, Yan C, Chen X*, Jiang H*. Potential Transmission of Alpha-Synuclein from the Gastrointestinal Tract to the Substantia Nigra along the Vagal Afferent Pathway. Neurosci Bull. 2025 Sep 20. Online ahead of print.

2. Dai Y, Bi M, Jiao Q, Du X, Chen X, Yan C*, Jiang H*.Deciphering the Janus-Faced Nature of the Apolipoprotein Superfamily in Parkinsonian Neurodegeneration: Molecular Crosstalk Between the Astroglial Secretome and Neuronal Homeostasis. Mov Disord. 2025 Jul 14.Online ahead of print.

3. Li H, Qiao Z, Xiao X, Cao X, Li Z, Liu M, Jiao Q, Chen X, Du X*, Jiang H*. G protein-coupled receptors: A golden key to the treasure-trove of neurodegenerative diseases. Clin Nutr. 2025 Mar;46:155-168.

4. Huan X, Li J, Chu Z, Zhang H, Cheng L, Lun P, Du X, Chen X, Jiao Q*, Jiang H*. Dysregulation of Iron Homeostasis Mediated by FTH Increases Ferroptosis Sensitivity in TP53-Mutant Glioblastoma. Neurosci Bull. 2025 Apr;41(4):569-582.

5. Liu M, Liu S, Lin Z, Chen X, Jiao Q, Du X, Jiang H*. Targeting the Interplay Between Autophagy and the Nrf2 Pathway in Parkinson's Disease with Potential Therapeutic Implications. Biomolecules. 2025 Jan 19;15(1):149.

6. Yao Z, Jiao Q, Du X, Jia F, Chen X, Yan C, Jiang H*. Ferroptosis in Parkinson's disease -- The iron-related degenerative disease. Ageing Res Rev. 2024 Nov;101:102477.

7. Xiao X#, Tang T#, Bi M#, Liu J, Liu M, Jiao Q, Chen X, Yan C, Du X*, Jiang H*. GHSR deficiency exacerbates Parkinson's disease pathology by impairing autophagy. Redox Biol. 2024 Oct:76:103322.

8. Yao Z, Jia F, Wang S, Jiao Q, Du X, Chen X, Jiang H*. The involvement of IRP2-induced ferroptosis through the p53-SLC7A11-ALOX12 pathway in Parkinson's disease. Free Radic Biol Med. 2024 Sep;222:386-396.

9. Dai Y, Bi M, Jiao Q, Du X, Yan C*, Jiang H*. Astrocyte-derived apolipoprotein D is required for neuronal survival in Parkinson's disease. NPJ Parkinsons Dis. 2024 Aug 2;10(1):143.

10. Li B#, Xiao X#, Bi M, Jiao Q, Chen X, Yan C, Du X*, Jiang H*. Modulating α-synuclein propagation and decomposition: Implications in Parkinson's disease therapy. Ageing Res Rev. 2024 Jul:98:102319.

11. Xiao X, Bi M, Du X*, Jiang H*. The ATP-sensitive potassium channel: a therapeutic target for neurodegeneration? Expert Opin Ther Targets. 2023 Jul;27(7):517-521.

12. Tang T, Bi M, Diao M, Zhang X, Chen L, Xiao X, Jiao Q, Chen X, Yan C, Du X*, Jiang H*. Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson's disease mouse model through activating GHS-R1a/D2R heterodimer. Acta Pharmacol Sin. 2023 Aug;44(8):1564-1575.

13. Chen L, Huan X, Jia F, Zhang Z, Bi M, Fu L, Du X, Chen X, Yan C, Jiao Q*, Jiang H*. Deubiquitylase OTUD3 Mediates Endoplasmic Reticulum Stress through Regulating Fortilin Stability to Restrain Dopaminergic Neurons Apoptosis. Antioxidants (Basel). 2023 Mar 26;12(4):809.

14. Chen L, Bi M, Zhang Z, Du X, Chen X, Jiao Q*, Jiang H*. The functions of IRE1α in neurodegenerative diseases: Beyond ER stress. Ageing Res Rev. 2022 Dec:82:101774.

15. Liu Y#, Wang W#, Song N#, Jiao J, Jia F, Du X, Chen X, Yan C, Jiao J, Jiao Q*, Jiang H*. Ghrelin bridges DMV neuropathology and GI dysfunction in the early stages of Parkinson's disease. Adv Sci (Weinh). 2022 Oct;9(30):e2203020.

16. Dang X, Huan X, Du X, Chen X, Bi M, Yan C, Jiao Q*, Jiang H*. Correlation of ferroptosis and other types of cell death in neurodegenerative diseases. Neurosci Bull. 2022 Aug;38(8):938-952.

17. Lv J, Xiao X, Bi M, Tang T, Kong D, Diao M, Jiao Q, Chen X, Yan C, Du X*, Jiang H*. ATP-sensitive potassium channels: a double-edged sword in neurodegenerative diseases. Ageing Res Rev. 2022 Jun 17;101676.

18. Liu M#, Liu C#, Xiao X, Han S, Bi M, Jiao Q, Chen X, Yan C, Du X*, Jiang H*. Role of upregulation of the KATP channel subunit SUR1 in dopaminergic neuron degeneration in Parkinson’s disease. Aging Cell. 2022 May;21(5):e13618.

19. Chen X, Dong J, Jiao Q, Du X, Bi M, Jiang H*. “Sibling” Battle or Harmony: Crosstalk between Nesfatin-1 and Ghrelin. Cell Mol Life Sci. 2022 Mar 3;79(3):169.

20. Yao Z, Fu L, Jia F, Bi M, Jiao Q, Chen X, Du X, Jiang H*. Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism. Ageing Res Rev. 2022 Jan:73:101511.


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